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Airflow-directed In Situ Portable Electrospinning Setup For Rapid Hemostasis

2019-03-26


           
Airflow-directed In Situ Portable Electrospinning Setup For Rapid Hemostasis

Similar to this concept, Long and coworkers proposed an airflow-directed in situ portable electrospinning setup for rapid hemostasis, as shown in Fig. 2.17A (Jiang et al., 2014). The airflowdirected in situ electrospinning device mainly consists of four elements: a high-voltage power supply, a syringe pump, an air pump, and a home-made handle with a spinneret head. The positive electrode of the power supply is connected to the spinneret head to provide a high voltage of about 6-10 kV, which is necessary to generate electrospun fibers. A syringe is also connected to the spinneret and pushed by the syringe pump to provide a stable and appropriate feed rate. To assist in electrospinning and control the fiber deposition range, an air pump is connected to the home-made handle and spinneret head, which has a coaxial structure. The airflow also can be used to clean wounds before electrospinning, and its appropriate velocity is about 12 L/min. By using this in situ portable apparatus, US FDA-approved N-octyl-2-cyanoacrylate (NOCA), a commercial tissue adhesive (medical glue), can be electrospun into fibers to reconstruct a nanostructured coating in dozens of seconds, and can be deposited in a controlled region of injury for rapid hemostasis (Fig. 2.17B). Moreover, this device has shown several advantages such as high efficiency and low toxicity (Dong et al., 2015). In addition, Long and colleagues covered a simulated open head wound with electrospun NOCA medical glue fibers by using this device (Lv et al., 2016).

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