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Chinese Nano Hemostatic Technology Continue Developing
2018-03-01

Counting The Electrospinning Nano Hemostatic Technology


Hemostasis is an important step of medical cure. The injury and operation of the patient’s liver, spleen or other tissues and organs needed adequate hemostasis. When sudden wound happened in daily life, also needed quick hemostasis. It’s very important to stop bleeding rapidly when having wound acute treatment in the hostile environment of war and complex emergency. With the development of international nanotechnology, China also made a significant breakthrough in the medicophysics research area of nano hemostatic technology. This article briefly introduced two electrospinning nano hemostatic technology.


Nano hemostatic technology number1:


A kind of airflow assisted in situ electrospinning device. It in situ electrospun C5H5NO2 medical adhesive to nanofiber, realized the large area wound of viscera stopping bleeding rapidly.  

According to the report of the Phoenix New Media Limited, a multi-disciplinary team which formed by professor Kai Jiang from PLA General Hospital Hepatobiliary Surgery, professor Yunze Long from Qingdao University and researcher Xingyu Jiang from National Nanotechnology Center cooperatively designed a kind of airflow assisted in situ electrospinning device. They used this technology for doing an experiment of live pig liver excision and hemostasis first time internationally.


 The results show that this device can in situ electrospin C5H5NO2 medical adhesive to nanofiber. C5H5NO2 medical adhesive is the main ingredient of superglue. The Food and Drug Administration of USA has approved it to be applied to human body hemostasis. Under the guiding of airflow, it deposited precisely and equably on the surface of the wound, formed a compact membrane, realized the large area wound of viscera stopping bleeding rapidly. The related achievements have been published on the periodical Chemistry World of the Royal Society of Chemistry. With new ideas, this technology will dig deep to discover the potential of existing medical hemostatic materials and change their traditional application mode. It’s hopeful of reducing the operation time, cutting the medical cost, improving the safety of the operation, making the hemostasis of surgical resection of substantial organ rapid and reliable in the future, making abandoning traditional hemovac possible.


Nano hemostatic technology number2:

Using coaxial electrospinning device to manufacture chitosan.

Patent name: chitosan nanofiber hemostatic material and its manufacture method
Application No.: CN201310424666.5

This invention provided a kind of chitosan nanofiber hemostatic material and its manufacture method. Wherein the chitosan nanofiber material is a kind of core-shell nanofiber. In the nanofiber, the chitosan formed the shell, the poval formed the core. The diameter of the core-shell nanofiber is between 100nm to 20μm. In this invention, using the coaxial electrospinning technology to manufacture the CS-PVP core-shell nanofiber which with high chitosan content and high specific surface area. The nanofiber is applying to the hemostasis of living organism. Experiments proved that the CS-PVP nanofiber has good biocompatibility and excellent hemostatic properties, not only kept the good hydroscopicity and spinnability of PVP material, but also combined the excellent antibacterial hemostasis properties of the CS material, is capable of using for clinically wound surface’s hemostasis. Besides, its manufacture method is simple and quick, high efficiency.


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