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Anti-infective Composite Electrospinning Nanofiber Membrane Repair Patch after Surgery


Sputum is also called small intestines. Simply put, sputum is a tear or a hole in the abdominal muscle tissue. The organ or tissue such as the small intestine of the patient leaves the original position through this hole and protrudes into other parts of the body. If left untreated, the original abdominal wall defect will become larger and larger. In severe cases, there is also a reversible mass that cannot be pushed back into the body, accompanied by abdominal cramps, vomiting, abdominal distension, that is, prominent intestinal cavity or other organs in the abdominal cavity are caught by the ankle ring and can no longer be returned to the abdominal cavity. It is medically called the incarceration. This situation can easily lead to ischemia and necrosis of the intestine or other intra-abdominal organs. If it is not operated in time, it will endanger life. It is conservatively estimated that there are about 2 million patients with inguinal hernia in China each year, and there are only about 80,000 patients who actually undergo groin repair surgery, which means that more than 1.9 million untreated patients are still suffering from all kinds of pain.

According to the official data of the American College of Family Physicians, except for some children, sputum can't be self-healing. At present, hernia repair is the only option to cure abdominal wall hernia. Hernia repair refers to the treatment of hernia by surgery. It can be divided into three categories: traditional hernia repair, tension-free repair of hernia patch (or filling repair) and laparoscopic repair. At present, tension-free repair of sputum patch has become a routine operation for clinical doctors to treat abdominal wall hernia, and sacral patch is an implant material for tension-free repair and laparoscopic repair. Laparoscopic repair is a minimally invasive procedure, but it has not been widely carried out. It is technically inferior to the repair of tension-free patch.

The development of artificial repair materials can be traced back to the inferior hernia repair of Laroque with a metal mesh in 1919. However, due to its inability to resist folding, the compliance was poor and it was eliminated when it was not commercialized. In the mid-20th century, with the emergence and rapid development of new synthetic materials, the technology of using enamel repair with organic polymer materials began to be applied in clinical practice and achieved remarkable results. However, although sputum patches prepared from various polymer materials bring many advantages in clinical applications, sputum patches prepared from various polymer materials have certain infection problems due to rejection in the host.

In order to improve the medical effect of sputum repair tablets, reduce the suffering of patients, and improve the anti-adhesion and anti-infective properties of sputum repair materials, it has been the goal pursued by researchers.

The electrospinning method is a simple and effective processing technology for preparing polymer nano-nonwoven fabrics which has been rapidly developed in the past decade. Since the obtained fiber material has an extremely large specific surface area, a surface area to volume ratio and a high porosity, it imparts a strong adsorption force to the material as well as good filterability, barrier property, adhesion and heat retention, and the porous structure is advantageous for nutrients. Therefore, electrospinning nanofibers are widely used in biomedical applications, such as post-operative anti-adhesion materials, wound coating materials, drug and gene delivery materials, tissue engineering scaffold materials, etc.

A composite electrospinning nanofiber membrane enamel patch for anti-infection after clinical operation can be prepared by an electrospinning method, and the enamel patch of the invention comprises a polymer nanofiber membrane substrate prepared by an electrospinning method. The biodegradable polymer nanofiber functional membrane loaded with the anti-infective drug is prepared by the electrospinning method in which the polymer nanofiber membrane substrate is connected. The polymer nanofiber membrane substrate is soft and has good mechanical properties, does not cause damage to internal organs, and allows the internal organs to be fixed at a postoperative recovery position; the electrospinning nanofiber functional membrane loaded with an anti-infective drug has The suitable degradation rate, with the degradation of the material, the release of anti-infective drugs, can effectively prevent inflammation caused by postoperative infection and wound contamination.

The composite electrospinning nanofiber membrane enamel patch can provide sufficient mechanical properties for a long time and maintain the strength of the abdominal wall for long-term maintenance, and can be widely used in hernia repair. The shape of the composite electrospinning nanofiber membrane enamel patch can be tailored to the wound. After being implanted into the human body, the composite electrospinning nanofiber membrane repairing patch can effectively reduce the inflammatory reaction caused by postoperative infection and reduce the suffering of the patient.


(Some materials are organized in the patent network, the invention patent number is CN104096272A)

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